Worldwide H. pylori antibiotic resistance: a systematic review

摘要: Background and Aims. Prevalence of H. pylori antibiotic resistance is increasing worldwide, it the main factor affecting efficacy current therapeutic regimens. Our aim was to review recent data on towards antibiotics in different countries.Methods. A systematic studies concerning primary published through January 2006 December 2009 performed. Data were analyzed according geographic area, age, sex, gastroduodenal pathology.Results. The overall rates 17.2% (95% CI: 16.5-17.9%) for clarithromycin, 26.7% 25.2-28.1%) metronidazole, 11.2% 9.6-12.7%) amoxycillin, 16.2% 14.4-18%) levofloxacin, 5.9% 4.7-7.1%) tetracycline, 1.4% 0.81-9%) rifabutin 9.6% 8.5-10.7%) multiple antibiotics. Prevalence rate levofloxacin significantly increased from Europe Asia, America Africa. Tetracycline low (<3%) all countries, but Africa (43.9%). clarithromycin higher non-ulcer dyspepsia patients, whilst metronidazole peptic ulcer patients. Both resistances female than male regarding amoxicillin are highly conflicting.Conclusion. The worldwide has increased. Such a phenomenon may affect management countries.