Activation of melatonin receptor (MT1/2) promotes P-gp transporter in methamphetamine-induced toxicity on primary rat brain microvascular endothelial cells

作者： Pichaya Jumnongprakhon , Sivanan Sivasinprasasn , Piyarat Govitrapong , Chainarong Tocharus , Jiraporn Tocharus

DOI: 10.1016/J.TIV.2017.02.010

关键词:

摘要: Melatonin has been known as a neuroprotective agent for the central nervous system (CNS) and blood-brain barrier (BBB), which is primary structure that comes into contact with several neurotoxins including methamphetamine (METH). Previous studies have reported activation of melatonin receptors (MT1/2) by could protect against METH-induced toxicity in brain endothelial cells via mechanisms. However, its effects on P-glycoprotein (P-gp) transporter, active efflux pump involved cell homeostasis, are still unclear. Thus, this study investigated role METH-impaired P-gp transporter rat microvascular (BMVECs). The results showed METH impaired function significantly decreasing Rho123 expression, caused significant increase intracellular accumulation Rho123, these responses were reversed interaction receptors. Blockade verapamil oxidative stress, apoptosis, integrity impairment after treatment, be melatonin. Our results, together previous findings, suggest protects protective was at least partially mediated regulation transporter. essential protecting BBB METH.

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Activation of melatonin receptor (MT1/2) promotes P-gp transporter in methamphetamine-induced toxicity on primary rat brain microvascular endothelial cells

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Activation of melatonin receptor (MT1/2) promotes P-gp transporter in methamphetamine-induced toxicity on primary rat brain microvascular endothelial cells

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