Hepatitis C Virus Infection, Autophagy, and Innate Immune Response
作者： Shubham Shrivastava , Ratna B. Ray
DOI: 10.1016/B978-0-12-405529-2.00011-1
关键词:
摘要: Hepatitis C virus (HCV) causes chronic infection in the majority of infected individuals, with potential to develop liver cirrhosis and eventually hepatocellular carcinoma during long course infection. HCV induces autophagy chronically patients, as well hepatocytes vitro. Innate immune responses are frontline defense mechanism against invading viral pathogens immediately after has evolved various strategies circumvent innate responses, especially by targeting interferon (IFN) production effector functions IFN-stimulated gene (ISG) expression. In a series manipulations response, exploits cellular homeostasis process inducing suppress IFN induction. Interaction between host’s response provides mechanistic insights into virus’ ability establish persistent individuals. this review, we summarize role
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