Microarray analysis identifies interferon β-regulated genes in multiple sclerosis
作者： Fumiko Koike , Jun-ichi Satoh , Sachiko Miyake , Toshiyuki Yamamoto , Mitsuru Kawai
DOI: 10.1016/S0165-5728(03)00155-3
关键词:
摘要: The molecular mechanisms for the interferon beta (IFNbeta) treatment of multiple sclerosis (MS) remain to be characterized. Using cDNA microarray technology, we have compared gene expression profile T and non-T cells derived from relapsing-remitting MS before after with IFNbeta-1b. IFNbeta significantly altered 21 genes out 1263 at 3 6 months treatment. These included nine IFN-responsive promoter elements. Whereas there was no change in Th1 or Th2 marker genes, some changes were unexpected but coincided beneficial effect MS.
jni-journal.com
elsevier.com参考文章(53)
Y. Iwakura, M. Asano, Y. Nishimune, Y. Kawade, Male sterility of transgenic mice carrying exogenous mouse interferon-beta gene under the control of the metallothionein enhancer-promoter. The EMBO Journal. ,vol. 7, pp. 3757- 3762 ,(1988) , 10.1002/J.1460-2075.1988.TB03259.X
Angus W. Thomson, The cytokine handbook Academic Press. ,(1994)
T.H. Lee, L. Klampfer, T.B. Shows, J. Vilcek, Transcriptional regulation of TSG6, a tumor necrosis factor- and interleukin-1-inducible primary response gene coding for a secreted hyaluronan-binding protein. Journal of Biological Chemistry. ,vol. 268, pp. 6154- 6160 ,(1993) , 10.1016/S0021-9258(18)53232-4
A D Luster, R L Weinshank, R Feinman, J V Ravetch, Molecular and biochemical characterization of a novel gamma-interferon-inducible protein. Journal of Biological Chemistry. ,vol. 263, pp. 12036- 12043 ,(1988) , 10.1016/S0021-9258(18)37889-X
A. C. Porter, Y. Chernajovsky, T. C. Dale, C. S. Gilbert, G. R. Stark, I. M. Kerr, Interferon response element of the human gene 6-16. The EMBO Journal. ,vol. 7, pp. 85- 92 ,(1988) , 10.1002/J.1460-2075.1988.TB02786.X
Paul Basset, Marie-Christine Rio, Jean-Pierre Bellocq, Marie-Geneviève Mattei, Pierre Chambon, Marie-Pierre Chenard, Ulla B. Rasmussen, Catherine Wolf, Identification of a New Interferon-α-inducible Gene (p27) on Human Chromosome 14q32 and Its Expression in Breast Carcinoma Cancer Research. ,vol. 53, pp. 4096- 4101 ,(1993)
B N Cronstein, J Vilcek, H G Wisniewski, D Naime, J C Hua, D M Poppers, TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-alpha-inhibitor and exerts a strong anti-inflammatory effect in vivo. Journal of Immunology. ,vol. 156, pp. 1609- 1615 ,(1996)
P Wong, C W Severns, N B Guyer, T M Wright, A unique palindromic element mediates gamma interferon induction of mig gene expression. Molecular and Cellular Biology. ,vol. 14, pp. 914- 922 ,(1994) , 10.1128/MCB.14.2.914
N. Reich, B. Evans, D. Levy, D. Fahey, E. Knight, J. E. Darnell, Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element Proceedings of the National Academy of Sciences of the United States of America. ,vol. 84, pp. 6394- 6398 ,(1987) , 10.1073/PNAS.84.18.6394
C S Chiang, H C Powell, L H Gold, A Samimi, I L Campbell, Macrophage/microglial-mediated primary demyelination and motor disease induced by the central nervous system production of interleukin-3 in transgenic mice. Journal of Clinical Investigation. ,vol. 97, pp. 1512- 1524 ,(1996) , 10.1172/JCI118574