Ocular motor delayed-response task performance among patients with schizophrenia and their biological relatives

摘要: Schizophrenia patients and their relatives have saccadic abnormalities characterized by problems inhibiting a response. The dorsolateral prefrontal cortex its associated circuitry ostensibly mediate inhibition support correct delayed response performance. In this context, two components of task performance are interest: memory saccade metrics error saccades made during the delay. To evaluate these variables, an ocular motor was presented to 23 schizophrenia patients, 25 first-degree biological relatives, 19 normal subjects. measure that best differentiated groups increased frequency generated delay subjects relatives. Decreased gain also similar pattern results demonstrated with suggests on tasks, either alone or in combination other may provide useful information about neural substrates liability for developing schizophrenia.