Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95
作者： H. Kornau , L. Schenker , M. Kennedy , P. Seeburg
关键词:
摘要: The N-methyl-D-aspartate (NMDA) receptor subserves synaptic glutamate-induced transmission and plasticity in central neurons. yeast two-hybrid system was used to show that the cytoplasmic tails of NMDA subunits interact with a prominent postsynaptic density protein PSD-95. second PDZ domain PSD-95 binds seven-amino acid, COOH-terminal containing terminal tSXV motif (where S is serine, X any amino V valine) common NR2 certain NR1 splice forms. Transcripts encoding are expressed pattern similar receptors, NR2B subunit co-localizes cultured rat hippocampal interaction these proteins may affect excitatory synapses.
sciencemag.org
harvard.edu
core.ac.uk
mpg.de参考文章(39)
U. Kistner, B.M. Wenzel, R.W. Veh, C. Cases-Langhoff, A.M. Garner, U. Appeltauer, B. Voss, E.D. Gundelfinger, C.C. Garner, SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A. Journal of Biological Chemistry. ,vol. 268, pp. 4580- 4583 ,(1993) , 10.1016/S0021-9258(18)53433-5
W. Stühmer, J.P. Ruppersberg, K.H. Schröter, B. Sakmann, M. Stocker, K.P. Giese, A. Perschke, A. Baumann, O. Pongs, Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain The EMBO Journal. ,vol. 8, pp. 3235- 3244 ,(1989) , 10.1002/J.1460-2075.1989.TB08483.X
DJ Laurie, PH Seeburg, Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA The Journal of Neuroscience. ,vol. 14, pp. 3180- 3194 ,(1994) , 10.1523/JNEUROSCI.14-05-03180.1994
H Bading, D. Ginty, M. Greenberg, Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways Science. ,vol. 260, pp. 181- 186 ,(1993) , 10.1126/SCIENCE.8097060
Henry R. Bourne, Roger Nicoll, Molecular machines integrate coincident synaptic signals Cell. ,vol. 72, pp. 65- 75 ,(1993) , 10.1016/S0092-8674(05)80029-7
T Sato, S Irie, S Kitada, J. Reed, FAP-1 : a protein tyrosine phosphatase that associates with fas Science. ,vol. 268, pp. 411- 415 ,(1995) , 10.1126/SCIENCE.7536343
C. T. Chien, P. L. Bartel, R. Sternglanz, S. Fields, The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 9578- 9582 ,(1991) , 10.1073/PNAS.88.21.9578
I. S. Moon, M. L. Apperson, M. B. Kennedy, The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 3954- 3958 ,(1994) , 10.1073/PNAS.91.9.3954
Stanley Fields, Ok-kyu Song, A novel genetic system to detect protein-protein interactions. Nature. ,vol. 340, pp. 245- 246 ,(1989) , 10.1038/340245A0
L. Nowak, P. Bregestovski, P. Ascher, A. Herbet, A. Prochiantz, Magnesium gates glutamate-activated channels in mouse central neurones Nature. ,vol. 307, pp. 462- 465 ,(1984) , 10.1038/307462A0