What we talk about when we talk about nanoclusters.

摘要: Superresolution microscopy results have sparked the idea that many membrane proteins are not randomly distributed across plasma but instead arranged in nanoclusters. Frequently, these new seemed to confirm older data based on biochemical and electron experiments. Recently, however, it was recognized multiple countings of very same fluorescently labeled protein molecule can be easily confused with true clusters. Various strategies been developed, which intended solve problem discriminating clusters from imaging artifacts. We believe there is currently no perfect algorithm for this problem; instead, different approaches strengths weaknesses. In review, we discuss single localization view its ability detect nanoclusters proteins. To capture views nanoclustering, chose an unconventional style article: placed scientific content setting a fictive conference, where five researchers fields detecting quantifying Using style, feel common research areas well illustrated. Similarities short story by Raymond Carver unintentional.