Cytotoxicity and Mechanism of Action of the Marine-Derived Fungal Metabolite Trichodermamide B and Synthetic Analogues.
作者： Petra E. Jans , Adelphe M. Mfuh , Hadi D. Arman , Corena V. Shaffer , Oleg V. Larionov
DOI: 10.1021/ACS.JNATPROD.6B00963
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摘要: The trichodermamides are modified dipeptides isolated from a wide variety of fungi, including Trichoderma virens. Previous studies reported that trichodermamide B (2) initiated cytotoxicity in HCT-116 colorectal cancer cells, while A (1) was devoid activity. We recently developed an efficient total synthesis for the A–C (1–3). Multiple intermediates and analogues were produced, they evaluated biological effects to identify additional structure–activity relationships possibility simplified analogue would retain 2. antiproliferative 18 compounds evaluated, results show 2 four other active HeLa with IC50 values range 1.4–21 μM. Mechanism action revealed different spectra At IC85 concentration, caused S-phase accumulation cell death suggesting response DNA double-s...
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