Gut microbiome diversity and composition is associated with hypertension in women.

摘要: OBJECTIVES Animal studies support a role for the gut microbiota in hypertension development, but large human are lacking. Here, we investigated relationship between prevalence and microbial composition two cohorts. METHODS We included 871 unrelated TwinsUK women with faecal microbiome data (16s rRNA gene sequencing). Multivariable linear models adjusted age, age2 BMI as well MiRKAT models, were used to estimate association of alpha- beta-diversity metrics. To identify taxa associated hypertension, generalized additive model location scale shape was computed adjusting covariates multiple testing. Results replicated 448 from PREDICT-1. RESULTS found that measures alpha diversity significantly lower hypertensive cases [Beta(95% confidence interval, 95% CI) = -0.05 (-0.095 -0.004), P = 0.03] significant beta (FDR < 0.05). identified genera hypertension. The genus, Ruminiclostridium 6 less abundant [meta-analysis (95% CI) = -0.31 (-0.5 -0.13), P = 1 × 10-3]. uncultured microbe Erysipelotrichacea-UCG003 more CI) = 0.46 (0.3-0.62), P = 1 × 10-4]. genomically analysed 16 s sequence established 100% identity match genus Faecalibacillus. functionally annotated Ruminiclostridium, identifying 83 metabolic pathways, including pathways previously linked blood pressure regulation. CONCLUSION In this observation, show Our results suggest targeting may be novel means prevent or treat