Lack of effects of isoflavones on the lipid profile of Brazilian postmenopausal women.

摘要: Abstract Objective To evaluate the effects of soy isoflavone supplementation on profile lipid and endogenous hormone levels. Methods In this double-blind, placebo-controlled study, 47 postmenopausal women 47–66 y age received 40 mg ( n = 25) or casein placebo 22). Cardiovascular risk factors were assessed by evaluating at baseline after 6 mo treatment. examine regime levels, follicle-stimulating β-estradiol measured. Urinary concentrations (genistein daidzein) measured as markers both compliance absorption using high performance liquid chromatography. Baseline characteristics compared unpaired Student's t -test. Within-group changes determined paired -test comparison between groups analysis variance. Results Lipid levels (low-density lipoprotein total cholesterol) similarly decreased in groups. High-density increased significantly cannot thus be attributable to treatment; reason for such variation is unknown can attributed chance bias (even that a real effect perhaps spontaneous exercise dietary habits patients their inclusion). Furthermore, very low-density triacylglycerol non-significant manner. Conclusion The results present study do not support any biologically significant estrogenic parameters assessed. Further research will necessary definitively assess safety efficacy isoflavone.