The effect of Apremilast on signal transduction and IL-10 production in CD39high regulatory B cells in patients with psoriatic arthritis.

摘要: Background IL-10-producing regulatory B cells (Bregs) are of great importance in autoimmunity, as they inhibit proinflammatory T cells. We have shown that Bregs psoriatic arthritis(PsA) were decreased and inversely correlated with IFNγ+T (TH1 cells) IL-17+ (TH17 cells). overexpression CD39 also inhibitory effects on Preliminary results Our preliminary data showed Apremilast, a phosphodiesterase-4(PDE-4) inhibitor, used the treatment PsA psoriasis (Ps) increased reduced IFNγ+CD3+ IL-17+CD3+ found activation p38MAP kinase transcription factor STAT3, two important signaling pathways IL-10 production, PsA. Specific Aims The aim this research proposal is to study for first time immunomodulatory effect Apremilast peripheral blood mononuclear (PBMCs) CD39high Ps. Methods will expression from patients Ps before after their relation IFNγ+ Activation CREB (cAMP response element-binding protein), p38MAPK PBMCs Apremilast. cell IFNγ IL-17 production be studied. Significance This elucidate molecular better define