Thoughts, behaviour, and brain dynamics during navigation in the real world.
作者： Hugo J. Spiers , Eleanor A. Maguire
DOI: 10.1016/J.NEUROIMAGE.2006.01.037
关键词:
摘要: How does the human brain allow us to interact with and navigate through a constantly changing world? Whilst controlled experiments using functional imaging can give insightful snapshots of neuronal responses relatively simplified stimuli, they cannot hope mirror challenges faced by in real world. However, trying study mechanisms supporting daily living represents huge challenge. By combining neuroimaging, an accurate interactive virtual simulation bustling central London (UK), novel means ‘reading’ participants' thoughts whilst moved around city, we ascertained online neural correlates underpinning navigation this real-world context. A complex choreography dynamics was revealed comprising focal distributed, transient sustained activity. Our results provide new insights into specific roles individual areas, particular hippocampus, retrosplenial, frontal cortices, as well offering clues about how specialisations operate within dynamic systems.
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sci-hub.se 参考文章(46)
Georg Grön, Arthur P. Wunderlich, Manfred Spitzer, Reinhard Tomczak, Matthias W. Riepe, Brain activation during human navigation: gender-different neural networks as substrate of performance Nature Neuroscience. ,vol. 3, pp. 404- 408 ,(2000) , 10.1038/73980
P. C. Fletcher, J. M. Anderson, D. R. Shanks, R. Honey, T. A. Carpenter, T. Donovan, N. Papadakis, E. T. Bullmore, Responses of human frontal cortex to surprising events are predicted by formal associative learning theory Nature Neuroscience. ,vol. 4, pp. 1043- 1048 ,(2001) , 10.1038/NN733
Reginald G. Golledge, Wayfinding Behavior: Cognitive Mapping and Other Spatial Processes ,(2010)
R. Shayna Rosenbaum, Sandra Priselac, Stefan Köhler, Sandra E. Black, Fuqiang Gao, Lynn Nadel, Morris Moscovitch, Remote spatial memory in an amnesic person with extensive bilateral hippocampal lesions. Nature Neuroscience. ,vol. 3, pp. 1044- 1048 ,(2000) , 10.1038/79867
Etienne Koechlin, Gianpaolo Basso, Pietro Pietrini, Seth Panzer, Jordan Grafman, The role of the anterior prefrontal cortex in human cognition Nature. ,vol. 399, pp. 148- 151 ,(1999) , 10.1038/20178
Edmond Teng, Larry R. Squire, Memory for places learned long ago is intact after hippocampal damage Nature. ,vol. 400, pp. 675- 677 ,(1999) , 10.1038/23276
J. B. Rowe, The Prefrontal Cortex: Response Selection or Maintenance Within Working Memory? Science. ,vol. 288, pp. 1656- 1660 ,(2000) , 10.1126/SCIENCE.288.5471.1656
Neil Burgess, Eleanor A Maguire, John O'Keefe, The Human Hippocampus and Spatial and Episodic Memory Neuron. ,vol. 35, pp. 625- 641 ,(2002) , 10.1016/S0896-6273(02)00830-9
Neil Burgess, Suzanna Becker, John A. King, John O'Keefe, Memory for events and their spatial context: models and experiments Philosophical Transactions of the Royal Society B. ,vol. 356, pp. 1493- 1503 ,(2001) , 10.1098/RSTB.2001.0948
David S. Touretzky, A. David Redish, Theory of rodent navigation based on interacting representations of space Hippocampus. ,vol. 6, pp. 247- 270 ,(1996) , 10.1002/(SICI)1098-1063(1996)6:3<247::AID-HIPO4>3.0.CO;2-K