Genetic Diversity and Levels of Expression of Factor H Binding Protein among Carriage Isolates of Neisseria meningitidis

摘要: The prevention of meningococcal disease may be improved by recombinant vaccines such as 4CMenB and rLP2086 that target the factor H binding protein (fHbp), an immunogenic surface component Neisseria meningitidis present one three variants. Whether decrease carriage invasive isolates thus induce herd immunity is unknown. We analyzed genetic diversity levels expression fHbp among 268 strains compare them to those 467 strains. fhbp gene sequencing showed higher proportions variants 2 3 (p<0.0001). Carriage expressed lower (p<0.01) but remain high enough predict targeting antibodies against particularly in group B belonging frequent hypervirulent clonal complexes Europe North America (cc32, cc41/44, cc269). This suggests might reduce, at least part, acquisition some hyperinvasive isolates.