Improvement in self-reported quality of life with cognitive therapy for recurrent major depressive disorder

摘要: Abstract Background Major depressive disorder (MDD) is common, often recurrent and/or chronic. Theoretically, assessing quality of life (QoL) in addition to the current practice symptoms has potential offer a more comprehensive evaluation effects treatment interventions and course illness. Methods Before after acute-phase cognitive therapy (CT), 492 patients from Continuation Phase Cognitive Therapy Relapse Prevention trial ( Jarrett et al., 2013 , Thase, 2010 ) completed Quality Life Enjoyment Satisfaction Questionnaire (Q-LES-Q), Inventory Depressive Symptomatology Self-report (IDS-SR) Beck Depression (BDI); clinicians Hamilton Rating Scale for Depression-17-items. Repeated measures analysis variance evaluated improvement QoL before/after CT measured effect sizes. Change analyses assess clinical significance Hageman Arrindell, 1999 were conducted. Results At end CT, repeated measure produced statistically significant increase Q-LES-Q scores with sizes 0.48–1.3%; 76.9–91.4% reported clinically improvement. Yet, only 11–38.2% normalized. An covariance showed that change depression severity (covariates=IDS-SR, BDI) completely accounted scores. Limitations There two time points observation; lacked matched normal controls; generalizability constrained by sampling characteristics. Conclusions improves significantly MDD CT; however, this severity. Normalization all may require targeted, additional, longer treatment.