Rapports des Équivalents Structuraux de la Gamma G et de la Gamma A vis-à-vis de Certaines Activités Biologiques

作者: M. STEINBUCH , C. REUGE , R. AUDRAN , A. FAURE , M.M. ZAKIN

DOI: 10.1016/B978-0-08-013348-5.50033-8

关键词:

摘要: Summary The biological activities of immunoglobulins are not affected equally by chemical modifications. sites IgG responsible for the fixation complement and interaction with rheumatoid factor seem to be more labile than those concerned antibody activity. destruction Try Met causes a drastic modification both IgA, latter being even somewhat labile. present study confirmed earlier results showing that there is always parallelism between amount aggregated material anticomplementary activity in IgG. Certain chemically modified preparations having lost their become again after heating this can also found digestion papain certain Fc-fragments. However, other substituted molecules definitely devoid

参考文章(18)
Erhard Gross, Bernhard Witkop, Nonenzymatic Cleavage of Peptide Bonds: The Methionine Residues in Bovine Pancreatic Ribonuclease Journal of Biological Chemistry. ,vol. 237, pp. 1856- 1860 ,(1962) , 10.1016/S0021-9258(19)73948-9
Stratis Avrameas, Thérèse Ternynck, Biologically Active Water-insoluble Protein Polymers 1. THEIR USE FOR ISOLATION OF ANTIGENS AND ANTIBODIES Journal of Biological Chemistry. ,vol. 242, pp. 1651- 1659 ,(1967) , 10.1016/S0021-9258(18)96141-7
Anne D. Gounaris, Gertrude E. Perlmann, Succinylation of Pepsinogen Journal of Biological Chemistry. ,vol. 242, pp. 2739- 2745 ,(1967) , 10.1016/S0021-9258(18)99630-4
Robert L. Perlman, Harold Edelhoch, The Formation of Diiodotyrosine in Iodinated Human Serum Albumin Journal of Biological Chemistry. ,vol. 242, pp. 2416- 2422 ,(1967) , 10.1016/S0021-9258(18)95977-6
Charles L. Christian, Studies of Aggregated γ-Globulin: I. Sedimentation, Electrophoretic and Anticomplementary Properties Journal of Immunology. ,vol. 84, pp. 112- 116 ,(1960)
Kimishige Ishizaka, Teruko Ishizaka, Biologic activity of aggregated gamma-globulin. II. A study of various methods for aggregation and species differences. Journal of Immunology. ,vol. 85, pp. 163- 171 ,(1960)
R R Porter, The hydrolysis of rabbit γ-globulin and antibodies with crystalline papain Biochemical Journal. ,vol. 73, pp. 119- 127 ,(1959) , 10.1042/BJ0730119
Wilton E. Vannier, Donald C. Abele, Burton R. Andersen, Effects of Mild Periodate Oxidation on Antibodies Journal of Immunology. ,vol. 97, pp. 913- 924 ,(1966)
N.O Thorpe, H.F Deutsch, Studies on papain produced subunits of human γG-globulins—I Immunochemistry. ,vol. 3, pp. 317- 327 ,(1966) , 10.1016/0019-2791(66)90093-0