Increased risk of colorectal polyps in patients with non-alcoholic fatty liver disease undergoing liver transplant evaluation

摘要: Background: Screening colonoscopy is a standard part of the liver transplant (LT) evaluation process. We aimed to evaluate yield screening and determine whether non-alcoholic fatty disease (NAFLD) was associated with an increased risk colorectal neoplasia. Methods: retrospectively assessed all patients who completed LT at our center between 1/2008-12/2012. Patients Results: A total 1,102 were evaluated, 591 met inclusion criteria analyzed. The mean age 60 years, 67% male, 12% had NAFLD 88% other forms chronic disease. Overall, 42% polyp found on colonoscopy: 23% adenomas, 14% hyperplastic polyps 1% inflammatory polyps. In final multivariable model controlling for age, [odds ratio (OR) 2.41, P=0.001] history significant alcohol use (OR 1.69, P=0.004) predictive finding colonoscopy. addition, 1.95, P=0.02), 1.70, P=0.01) CTP class C 0.57, P=0.02) adenoma, age. Conclusions: in awaiting yields high rate (43%) adenoma (22%) detection, perhaps preventing accelerated progression carcinoma that can occur immunosuppressed post-LT patients. may be ~2 fold higher adenomas should carefully evaluated prior LT.