Prostate Cancer Progression to Androgen Independent Disease: The Role of the PI3K/AKT Pathway
作者： Jacqueline R , Yu Hao D Huang , Amit Persad , Sujata Pers
DOI: 10.5772/53483
关键词:
摘要: The development and progression of prostate cancer (CaP) is largely dependent on the dysregulation androgen/androgen receptor (AR) signaling pathway; though, mechanism CaP remains elusive. Initial treatments for included prosta‐ tectomy or radiation to destroy cancerous cells [1]. However, these were not curative more often than there recurrences metastases cancer. Mainstay that target androgen/AR pathway through anti-androgen androgen ablation therapies have been promising; yet again, seem fail as tumor progresses. This suggests dependence vary over time such alterations in availability, AR sensitivity promiscuity fuel a aggressive CaP.
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