Persistent skin colonization with Staphylococcus aureus in atopic dermatitis: relationship to clinical and immunological parameters.

摘要: Summary Background Staphylococcus aureus has important implications for the pathogenesis of atopic dermatitis (AD). In some patients S. can be eradicated from skin during anti-inflammatory treatment, while in others bacterial colonization is persistent. Potential mechanisms and features these two distinct groups are not known. Objective Accordingly, we studied relationships between ability to eliminate an treatment selected clinical immunological features. Methods Quantitative assessment on skin, nasal vestibule throat, serum IgE levels, CD4/CD8 T-cell ratio, lymphocyte proliferation phagocyte oxidative burst were determined exacerbation after 4 12 weeks using topical steroid oral antihistamine 34 with AD. Results was found all exacerbation. Disease severity scoring (SCORAD) correlated density bacteria. Treatment resulted a significant alleviation symptoms, which elimination 70% patients. remaining 30% patients, dense (more than 1010/cm2) colonization, persisted despite treatment. Patients persistent presented higher lower response staphylococcal enterotoxin B, phytohaemagluttinin anti-CD3. Persistence more common men. Conclusions AD differ clear appears related abnormalities parameters. Local antibiotic therapy should considered only colonization.