ADAMTS-13, von Willebrand factor and related parameters in severe sepsis and septic shock

摘要: BACKGROUND: Insufficient control of von Willebrand factor (VWF) multimer size as a result severely deficient ADAMTS-13 activity results in thrombotic thrombocytopenic purpura associated with microvascluar thrombosis and platelet consumption, features not seldom seen severe sepsis septic shock. METHODS: VWF parameters 40 patients or shock were compared those healthy controls the same age gender correlated clinical findings outcome. RESULTS: was significantly lower than [median 60% (range 27-160%) vs. 110% 63-200%); P < 0.001]. behaved reciprocally both ristocetin cofactor (RCo) antigen (VWF:Ag) (P 0.001) higher controls. Neither nor disease severity, organ dysfunction However, contribution acute endothelial to renal impairment is suggested by propeptide soluble thrombomodulin levels increased creatinine values well their strong positive correlations (creatinine r(s) = 0.484, 0.001; 0.596, 0.001). CONCLUSIONS: are but have no prognostic value regarding