CYP2D6 gene polymorphism as a probable risk factor for Alzheimer's disease and Parkinson's disease with dementia.

摘要: BACKGROUND AND PURPOSE The theory of multifactorial inheritance is considered in the pathogenesis sporadic Alzheimer's disease (AD) and Parkinson's (PD); therefore, it makes genes regulating bioactivation or detoxification exogenous substances candidates sensitivity to diseases. aims study were: 1) determine genotypes CYP2D6 cytochrome (CYP2D6) patients with AD PD dementia; 2) evaluate relationship between genotype age onset disease, extent dementia PD, dose side effects L-dopa PD; 3) usefulness genotyping predicting predispositions AD. MATERIAL METHODS 53 aged 58-84 (mean 72.6) 52 51-82 70.4) were recruited. Each patient satisfied criteria for probable Diagnostic Statistical Manual Mental Disorders 4th edition, Mini-Mental State Examination, Clinical Dementia Rating Scale Global Deterioration used evaluation patients. scales used. Methods molecular biology genetic studies. RESULTS There no differences allele distribution was alleles advancement PD. No observed. CONCLUSION As there polymorphism does not seem be a factor predisposing these