Synthesis of Polysubstituted Pyrazoles by a Platinum-Catalyzed Sigmatropic Rearrangement/Cyclization Cascade
作者： Jia-Jie Wen , Hai-Tao Tang , Kai Xiong , Zong-Cang Ding , Zhuang-Ping Zhan
DOI: 10.1021/OL502968C
关键词:
摘要: A highly efficient Pt-catalyzed [3,3] sigmatropic rearrangement/cyclization cascade of N-propargylhydrazones is reported. The process provides expedient access to a variety functionalized pyrazoles. substrate has good substituted group compatibility, and the bioactive 3-CF3 pyrazoles could be synthesized easily with this method.
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