Association of Endometrial Cancer Risk With Postmenopausal Bleeding in Women: A Systematic Review and Meta-analysis.

摘要: Importance As the worldwide burden of endometrial cancer continues to rise, interest is growing in evaluation early detection and prevention strategies among women at increased risk. Focusing efforts on with postmenopausal bleeding (PMB), a common symptom cancer, may be useful strategy; however, PMB not specific for often caused by benign conditions. Objective To provide reference prevalence cancers risk PMB. Data Sources For this systematic review meta-analysis, PubMed Embase were searched English-language studies published January 1, 1977, through 31, 2017. Study Selection Observational reporting unselected populations selected. Extraction Synthesis Two independent reviewers evaluated study quality bias using items from Newcastle-Ottawa Quality Assessment Scale Diagnostic Accuracy Studies tool. that included highly selected populations, lacked detailed inclusion criteria, and/or 25 or fewer excluded. Main Outcomes Measures The pooled Results A total 129 unique studies, including 34 432 patients 6358 (40 790 women), analyzed. was 91% (95% CI, 87%-93%), irrespective tumor stage. 9% 8%-11%), estimates varying use hormone therapy (range, 7% [95% 6%-9%] 12% 9%-15%];P  Conclusions Relevance Early focused have potential capture as many 90% cancers; most will diagnosed cancer. These results can aid assessment clinical value new markers management help inform epidemiologic prediction models support decision making.