Boosting Learning Efficacy with Noninvasive Brain Stimulation in Intact and Brain-Damaged Humans.

摘要: Numerous behavioral studies have shown that visual function can improve with training, although perceptual refinements generally require weeks to months of training attain. This, along questions about long-term retention learning, limits practical and clinical applications many such paradigms. Here, we show for the first time in female male human participants just 10 d coupled transcranial random noise stimulation (tRNS) over areas causes dramatic improvements motion perception. Relative control conditions anodal stimulation, tRNS-enhanced learning was at least twice as fast, and, crucially, it persisted 6 after end stimulation. Notably, tRNS also boosted patients chronic cortical blindness, leading recovery processing blind field a period too short elicit enhancements alone. In sum, our results reveal remarkable enhancement capacity long-lasting plastic restorative changes when neuromodulatory intervention is training.SIGNIFICANCE STATEMENT Our work demonstrates brain dramatically reduce from weeks, lead fast improvement neurotypical subjects cortically patients, indicating potential procedure help restore damaged abilities currently untreatable dysfunctions. Together, these indicate critical role early its promoted by intervention.