Eukaryotic Transposable Elements as Mutagenic Agents

摘要: Recently, there have been major advances in our understanding of the molecular mechanisms underlying retrotransposition and a growing appreciation importance repetitive DNA sequences transposable elements shaping eukaryotic genome structure. This work has focused attention both on potential these genetic to act as mutagenic agents regulation such processes at cellular level. Many different experimental approaches yeast, Drosophila, mammalian systems, are now use characterize range mutational events mediated by study interplay host genes various forms environmental physiological stress, including damage, processes. Despite this progress, few efforts bring together interested investigators for explicit purpose reviewing assessing field. To create further interest field, conference was recently held within setting Banbury Center, devoted exclusively an in-depth evaluation current area. The brought experts areas retroviruses elements, cancer biology, damage repair, human risk assessment. Particular emphasis placed not only description ofmore » types mutations caused rearrangement but also involvement ''genomic stress'' modulation viral latency, alteration gene expression, mediation transpositional report continues Center tradition publishing reviews emerging biology central assessment biology. Individual papers were processed separately database.« less