Prodrug-based nano-drug delivery system for co-encapsulate paclitaxel and carboplatin for lung cancer treatment.
作者： Wen Zhang , Changzheng Li , Chengwu Shen , Yuguo Liu , Xiaoting Zhao
DOI: 10.3109/10717544.2015.1035466
关键词:
摘要: AbstractContext: Paclitaxel (PTX) and carboplatin (CBP) are widely used for the combined chemotherapy of non-small cell lung cancer (NSCLC). However, development multidrug resistance cells, as well systemic toxic side effects resulting from nonspecific localization anticancer drugs to non-tumor areas major obstacles success in treating cancers.Objective: This study aimed engineer a prodrug-based nano-drug delivery system co-encapsulate hydrophilic hydrophobic anti-tumor (PTX). was expected resolve cause by single drug, dual-drug-loaded liposome also planned specifically target cells without obvious influence on normal tissues.Methods: In this paper, PLGA-PEG-CBP synthesized conjugation between carboxylic group PLGA-PEG-COOH amino CBP. Then, self-assembled nanoparticles combination PTX (PTX/CB...
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