Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons.

摘要: Syngap1 haploinsufficiency is a common cause of sporadic intellectual disability. mutations disrupt developing pyramidal neurons, although it remains unclear if this process contributes to cognitive abnormalities. Here, we found that restricted forebrain glutamatergic neurons was sufficient cognition and removing from population prevented In contrast, manipulating function in GABAergic had no effect on cognition, excitability, or neurotransmission, highlighting the specificity within excitatory neurons. Interestingly, abnormalities were reliably predicted by emergence enhanced synaptic mature superficial cortical cells, which neurophysiological disruption caused dysfunction developing, but not adult, We conclude reduced mutants isolated damage This triggers secondary disruptions homeostasis perpetuates brain into adulthood.