Measures of Rabies Immunity

摘要: The immune status of an individual host or among a population is affected by important variables including the source and route potential natural exposure for vaccination consist vaccine type, potency, virus strain; schedule; factors. Although perhaps often overlooked, it essential to have basic understanding laboratory methods used measure assess host’s status. precision, accuracy, sensitivity, specificity method must be well defined. Moreover, “adequate,” acceptable, diagnostic value each clearly defined so that particular test result patient can meaningfully interpreted in relation patient’s history clinical management. Serology study immunological properties blood serum other bodily fluids. reasons performing rabies serology range from diagnosis infection investigation epitope anti-rabies glycoprotein monoclonal antibody. Characterization antibody’s affinity, specificity, quantity, neutralizing function, complement binding class/subclass are achieved various methods. Many serological techniques developed over past five decades differ not only their ability detect affinity antibodies, but also ease practicality with which they performed. To select appropriate appropriately interpret results, understand specific strengths, weaknesses, limitations available decision use assay should start purpose testing intended application results. Other factors consider complexity, degree precision and/or detection. Given importance RVNA levels prevention human animal rabies, guidelines adequate stated terms readily understood individuals-at-risk (whether animal) health care providers, both veterinary medical, who will recommendations management individuals. Across globe, there different official regulatory standards guidelines, national international drugs related product approvals. implementation these beginning work at bench level end process continues during products improvement protection health, direct assessment of, responses to, vaccines sources polyclonal rabies.