Fractalkine/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death.
作者： Masami Suzuki , Nazira El-Hage , Shiping Zou , Yun-Kyung Hahn , Mary E Sorrell
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摘要: Background Fractalkine/CX3CL1 and its cognate receptor CX3CR1 are abundantly expressed in the CNS. Fractalkine is an unusual C-X3-C motif chemokine that important neuron-microglial communication, a co-receptor for HIV infection, can be neuroprotective. To assess effects of fractalkine on opiate-HIV interactive neurotoxicity, wild-type murine striatal neurons were co-cultured with mixed glia from striata or Cx3cr1 knockout mice ± HIV-1 Tat and/or morphine. Time-lapse digital images continuously recorded at 20 min intervals up to 72 h using computer-aided microscopy track same cells repeatedly.
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