The role of amylin in the insulin resistance of non-insulin-dependent diabetes mellitus
作者： Brendan Leighton , Garth J.S. Cooper
DOI: 10.1016/0968-0004(90)90015-4
关键词:
摘要: Decreased responsiveness of glucose metabolism to insulin in skeletal muscle and the liver (insulin resistance or insensitivity) is characteristic many conditions, including non-insulin-dependent (type II) diabetes mellitus. Most current work this area centres on hypothesis that primary defect an impairment binding and/or transduction signal affected tissues. However, studies imply defects post-insulin receptor signaling pathways are importance causation resistance. Amylin, a novel pancreatic hormone, secreted along with from beta-cells, can modulate effects, produce liver.
core.ac.uk
manchester.ac.uk
elsevier.com参考文章(24)
R A Challis, L Budohoski, B McManus, E A Newsholme, Effects of an adenosine-receptor antagonist on insulin-resistance in soleus muscle from obese Zucker rats. Biochemical Journal. ,vol. 221, pp. 915- 917 ,(1984) , 10.1042/BJ2210915
A. Kanatsuka, H. Makino, H. Ohsawa, Y. Tokuyama, T. Yamaguchi, S. Yoshida, M. Adachi, Secretion of islet amyloid polypeptide in response to glucose FEBS Letters. ,vol. 259, pp. 199- 201 ,(1989) , 10.1016/0014-5793(89)81527-3
Yasuhiko Okimura, Kazuo Chihara, Hiromi Abe, Tetsuya Kita, Yoichi Kashio, Michiaki Sato, Takuo Fujita, Calcitonin gene-related peptide-like immunoreactivity in the central nervous system and peripheral organs of rats. Regulatory Peptides. ,vol. 17, pp. 327- 337 ,(1987) , 10.1016/0167-0115(87)90056-5
Masamitsu Nakazato, Junko Asai, Kenji Kangawa, Shigeru Matsukura, Hisayuki Matsuo, Establishment of radioimmunoassay for human islet amyloid polypeptide and its tissue content and plasma concentration Biochemical and Biophysical Research Communications. ,vol. 164, pp. 394- 399 ,(1989) , 10.1016/0006-291X(89)91732-4
A. Lukinius, E. Wilander, G. T. Westermark, U. Engstr�m, P. Westermark, Co-localization of islet amyloid polypeptide and insulin in the B cell secretory granules of the human pancreatic islets. Diabetologia. ,vol. 32, pp. 240- 244 ,(1989) , 10.1007/BF00285291
Peter P. Stein, William A. Hunt, Carolyn M. Johnson, Ralph A. DeFronzo, J.Douglas Smith, Insulin resistance in uremia: an in vivo and in vitro study. Metabolism-clinical and Experimental. ,vol. 38, pp. 562- 567 ,(1989) , 10.1016/0026-0495(89)90217-5
A. Golay, R. A. DeFronzo, E. Ferrannini, D. C. Simonson, D. Thorin, K. Acheson, D. Thi�baud, B. Curchod, E. J�quier, J. P. Felber, Oxidative and non-oxidative glucose metabolism in non-obese Type 2 (non-insulin-dependent) diabetic patients Diabetologia. ,vol. 31, pp. 585- 591 ,(1988) , 10.1007/BF00264764
O. Rosen, After insulin binds. Science. ,vol. 237, pp. 1452- 1458 ,(1987) , 10.1126/SCIENCE.2442814
R. A. DeFronzo, Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes. ,vol. 37, pp. 667- 687 ,(1988) , 10.2337/DIAB.37.6.667
Brendan Leighton, Garth J. S. Cooper, Pancreatic amylin and calcitonin gene-related peptide cause resistance to insulin in skeletal muscle in vitro Nature. ,vol. 335, pp. 632- 635 ,(1988) , 10.1038/335632A0