Competition between the DNA unwinding and strand pairing activities of the Werner and Bloom syndrome proteins
作者： Amrita Machwe , EnerlynM Lozada , Liren Xiao , DavidK Orren
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摘要: Background The premature aging and cancer-prone Werner Bloom syndromes are caused by defects in the RecQ helicase enzymes WRN BLM, respectively. Recently, both BLM (as well as several other members) have been shown to possess a strand annealing activity addition requisite DNA unwinding activity. Since an function would appear directly oppose action of helicase, we examined this study dynamic equilibrium between mediated either or BLM.
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