Acquired haemophilia: a case report and a clinical review

摘要: BACKGROUND Acquired haemophilia presents later in life and is due to acquired inhibitors factor VIII. The disorder very rare (about one case per million population year) but causes significant morbidity mortality. CASE REPORT We report the of a 57 year-old obese man who was admitted our Day Hospital for anemia. At admission we observed diffuse ecchymoses large subcutaneous hematoma inferior right hemithorax. Laboratory findings showed severe anemia, prolonged aPTT with normal PT platelet count. titer anti-factor VIII inhibitor Bethesda units resulted high confirmed diagnosis haemophilia. used recombinant activated VII (rFVIIa) control active bleeding prednisone, cyclophosphamide and, lastly, anti- CD 20 monoclonal antibody (rituximab) eliminate inhibitors. Unfortunately, on fourth week, patient suffered an extensive abdominal wall died. CONCLUSIONS underline importance not overlooking because bleedings associated can be life-threatening constitute medical emergency.