Developmental physiology of cestodes. V. Effects of vitamin deficient diets and host coprophagy prevention on development of Hymenolepis diminuta.

摘要: Effects of B vitamin deficient diets on Hymenolepis diminuta were studied. The worms markedly affected by a diet in all vitamins only when host coprophagy was prevented, but some effects noted from hosts where allowed. Very few could establish themselves coprophagy-prevented rats the diet, and growth weight, length, proglottid numbers, differentiation severely impaired. Further investigation showed that dietary absence pyridoxine responsible for foregoing effects. Pyridoxine exhibited abnormalities similar to those found worms. partially mitigated injected with 10 ,ug HCl/day while being fed diets. average size under these conditions about half controls. However, if jig provided or larger amounts HC1 injected, worm equal results imply B6 may be factor H. diminuta, obtain exocrino-enteric circulation it is absent ingesta. Little known requirements any cestode, although have received most attention. Hager (1941) observed, over period several months, thiamine had no effect egg production vitamins, supplemented thiamine, greatly decreased production. These experiments repeated Chandler (1943) Addis (1944) except they numbers recovered total length 14-, 28-, 30-day infections. They reported A, D, E, stunted worms, female rats. (1946) later presence none (niacin, pyridoxine, pantothenic acid, riboflavin, biotin, p-aminobenzoic inositol, choline, folic acid), either collectively individually, would support normal concluded (s) yeast, other than included, * This supported Grants AI-06153 5 TOI AI-226 NIH, U. S. Public Health Service. t Present address: Rockefeller University, New York, York 10021. Received publication 2 May 1969. necessary establishment because their complete contained yeast as source. Subsequently, Beck (1951) "B diets" both male diet" calcium pantothenate, acid each day excess daily requirement. Whether given mouth injection not stated. Under used investigators, did require diet; however, situation respect equivocal since dried brewer's included Hence, elimination accompanied major change comprised 9% diet. Although full implications such been investigated, data indicated replaced available resulted 52% reduction synthetic yeast-free consistent compared correct control i.e., one which