Camellia japonica Seeds Extract SuppressesLipid-induced Hypertriglyceridemia and Fat Accumulation in Mice.
作者： Masaru Ochiai , Tsutomu Nozaki , Masaki Kato , Ken-o Ishihara
DOI: 10.5650/JOS.ESS18138
关键词:
摘要: As the seed extract from Camellia japonica (CJ) contains saponins, inhibitory effects of pancreatic lipase activity and body fat accumulation are expected. To investigate anti-obesity effect CJ extract, ICR mice were fed with a high-fat diet that was either supplemented or not 1% for 53 days. Including in diets increased fecal excretion decreased weight gain lipid parameters plasma liver. In addition, lipid-induced hypertriglyceridemia delayed by single administration ddY mice. Small intestinal transit received but gastric emptying remained unchanged. These data demonstrate can suppress excess absorption, which lead to prevention diet-induced obesity.
sci-hub.se 参考文章(23)
Toshiyuki MURAKAMI, Junko NAKAMURA, Hisashi MATSUDA, Masayuki YOSHIKAWA, Bioactive Saponins and Glycosides. XV. Saponin Constituents with Gastroprotective Effect from the Seeds of Tea Plant, Camellia sinensis L. var. assamica PIERRE, Cultivated in Sri Lanka : Structures of Assamsaponins A, B, C, D, and E Chemical & Pharmaceutical Bulletin. ,vol. 47, pp. 1759- 1764 ,(1999) , 10.1248/CPB.47.1759
Toshio Morikawa, Ning Li, Akifumi Nagatomo, Hisashi Matsuda, Xian Li, Masayuki Yoshikawa, Triterpene saponins with gastroprotective effects from tea seed (the Seeds of Camellia sinensis) Journal of Natural Products. ,vol. 69, pp. 185- 190 ,(2006) , 10.1021/NP058097W
Jan Borén, Niina Matikainen, Martin Adiels, Marja-Riitta Taskinen, Postprandial hypertriglyceridemia as a coronary risk factor Clinica Chimica Acta. ,vol. 431, pp. 131- 142 ,(2014) , 10.1016/J.CCA.2014.01.015
Masayuki YOSHIKAWA, Emiko HARADA, Toshiyuki MURAKAMI, Hisashi MATSUDA, Johji YAMAHARA, Nobutoshi MURAKAMI, CAMELLIASAPONINS B1, B2, C1 AND C2, NEW TYPE INHIBITORS OF ETHANOL ABSORPTION IN RATS FROM THE SEEDS OF CAMELLIA JAPONICA L. Chemical & Pharmaceutical Bulletin. ,vol. 42, pp. 742- 744 ,(1994) , 10.1248/CPB.42.742
Masayuki YOSHIKAWA, Toshiyuki MURAKAMI, Satoshi YOSHIZUMI, Nobutoshi MURAKAMI, Johji YAMAHARA, Hisashi MATSUDA, Bioactive saponins and glycosides. V. Acylated polyhydroxyolean-12-ene triterpene oligoglycosides, camelliasaponins A1, A2, B1, B2, C1, and C2, from the seeds of Camellia japonica L.: structures and inhibitory activity on alcohol absorption. Chemical & Pharmaceutical Bulletin. ,vol. 44, pp. 1899- 1907 ,(1996) , 10.1248/CPB.44.1899
Masayuki Yoshikawa, Toshio Morikawa, Ning Li, Akifumi Nagatomo, Xian Li, Hisashi Matsuda, Bioactive Saponins and Glycosides. XXIII. Triterpene Saponins with Gastroprotective Effect from the Seeds of Camellia sinensis—Theasaponins E3, E4, E5, E6, and E7— Chemical & Pharmaceutical Bulletin. ,vol. 53, pp. 1559- 1564 ,(2005) , 10.1248/CPB.53.1559
Kazuma Yoshizumi, Kaoru Hirano, Hidehiro Ando, Yasuaki Hirai, Yoshiteru Ida, Tomoko Tsuji, Tamotsu Tanaka, Kiyoshi Satouchi, Junji Terao, Lupane-type saponins from leaves of Acanthopanax sessiliflorus and their inhibitory activity on pancreatic lipase. Journal of Agricultural and Food Chemistry. ,vol. 54, pp. 335- 341 ,(2006) , 10.1021/JF052047F
Cunai Cao, Hui Su, Xiuwei Yang, Zuohan Wei, Lijun Du, Jia Shen, Evidence of gastro-intestinal system as an active and toxic target of sasanqua saponins extract. Experimental and Toxicologic Pathology. ,vol. 60, pp. 43- 49 ,(2008) , 10.1016/J.ETP.2007.11.016
Ana de la Garza, Fermín Milagro, Noemí Boque, Javier Campión, J. Martínez, Natural inhibitors of pancreatic lipase as new players in obesity treatment. Planta Medica. ,vol. 77, pp. 773- 785 ,(2011) , 10.1055/S-0030-1270924
Tomomi Yamazaki, Kyoko Kishimoto, Osamu Ezaki, The ddY mouse: a model of postprandial hypertriglyceridemia in response to dietary fat Journal of Lipid Research. ,vol. 53, pp. 2024- 2037 ,(2012) , 10.1194/JLR.M023713