Are prostaglandins involved in atrial natriuretic peptide mechanisms of cardiovascular control

摘要: Atrial natriuretic peptide (ANP) can excite cardiac nerve endings and invoke a decrease in arterial blood pressure reduction renal sympathetic activity. Our laboratory has previously demonstrated that this depressor reflex was invoked by systemic injection of ANP not the direct application to epicardium, major locus for vagal afferents. We now examine whether inhibition prostaglandin synthesis impairs responses are normally associated with injections. Renal activity, pressure, heart rate were recorded anesthetized rats. Indomethacin used inhibit through cyclooxygenase pathway. The ANP-mediated observed when inhibited, did differ significantly from decreases these parameters inhibited. Heart remained unchanged. results suggest sympatho-inhibitory effects do require prostaglandins as intermediary compounds.