Understanding the Multifaceted Role of Human Down Syndrome Kinase DYRK1A

摘要: The dual-specificity tyrosine (Y) phosphorylation-regulated kinase DYRK1A, also known as Down syndrome (DS) kinase, is a dosage-dependent signaling that was originally shown to be highly expressed in DS patients consequence of trisomy 21. Although this evident some time ago, it only recent investigations the molecular roles DYRK1A wide range cellular processes are becoming increasingly apparent. Since initial knowledge on became through minibrain mnb, Drosophila homolog review will first summarize scientific reports and further expand well-established neuronal functions mammalian human DYRK1A. Recent across current decade have provided rather interesting compelling evidence establishing nonneuronal for including its role infection, immunity, cardiomyocyte biology, cancer, cell cycle control. latter part therefore focus detail emerging regulatory controlling Tau α-synuclein. Finally, Parkinson's disease outlined.