Exogenous fatty acid binding protein 4 promotes human prostate cancer cell progression.

摘要: Epidemiologic studies have found that obesity is associated with malignant grade and mortality in prostate cancer. Several adipokines been implicated as putative mediating factors between Fatty acid binding protein 4 (FABP4), a member of the cytoplasmic fatty multigene family, was recently identified novel adipokine. Although FABP4 released from adipocytes mean circulating concentrations are linked obesity, effects exogenous on cancer progression unclear. In this study, we examined human cell progression. treatment promoted serum-induced invasion vitro. Furthermore, oleic only if present medium. These promoting were reduced by inhibitor, which inhibits to acids. Immunostaining for showed taken up into DU145 cells three-dimensional culture. mice, inhibitor subcutaneous growth lung metastasis cells. Immunohistochemical analysis number apoptotic cells, positive cleaved caspase-3 PARP, increased tumors inhibitor-treated compared control mice. results suggest might promote Additionally, activated PI3K/Akt pathway, independently Thus, be key molecule understand mechanisms underlying obesity-prostate link.