Cyclosporine-induced deterioration in patients with AIDS

摘要: Eight patients with AIDS (acquired immune deficiency syndrome) but free of life-threatening infection were treated the immunosuppressive drug cyclosporine for a mean 53.9 days. The serum levels maintained in desired therapeutic range. All eight experienced severe toxic symptoms, which necessitated discontinuation therapy six. creatinine, urea and potassium rose during treatment fell after was stopped. total leukocyte count, hemoglobin level, platelet T-cell T4- T8-cell counts all markedly treatment. stopped, level remained low. No patient resolution symptoms therapy, condition improved results this pilot study indicate that does not alleviate, may worsen, laboratory findings AIDS.