Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke
作者： Matthew Traylor , Cathy R Zhang , Poneh Adib-Samii , William J Devan , Owen E Parsons
DOI: 10.1212/WNL.0000000000002263
关键词:
摘要: OBJECTIVE: For 3,670 stroke patients from the United Kingdom, States, Australia, Belgium, and Italy, we performed a genome-wide meta-analysis of white matter hyperintensity volumes (WMHV) on data imputed to 1000 Genomes reference dataset provide insights into disease mechanisms. METHODS: We first sought identify genetic associations with hyperintensities in population, then examined whether loci previously linked WMHV community populations are also associated patients. Having established that shared between 2 populations, testing which stroke-free overall when combined populations. RESULTS: There were no at significance All reported significant direction effect In suggestive (p < 5 × 10(-6)) (15 single nucleotide polymorphisms total) patients, 6 independent both Four these novel level (rs72934505 [NBEAL1], p = 2.2 10(-8); rs941898 [EVL], 4.0 rs962888 [C1QL1], 1.1 rs9515201 [COL4A2], 6.9 10(-9)). CONCLUSIONS: Genetic otherwise healthy individuals stroke, indicating common susceptibility cerebral small vessel disease.
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