Serum sclerostin and DKK1 in relation to exercise against bone loss in experimental bed rest

摘要: The impact of effective exercise against bone loss during experimental bed rest appears to be associated with increases in formation rather than reductions resorption. Sclerostin and dickkopf-1 are important inhibitors osteoblast activity. We hypothesized that would prevent sclerostin dickkopf-1. Twenty-four male subjects performed resistive vibration (RVE; n = 7), only (RE; 8), or no (control 9) 60 days (2nd Berlin BedRest Study). measured serum levels BAP, CTX-I, iPTH, calcium, sclerostin, at 16 time-points up 1 year after rest. In inactive control, an initial increase both BAP increased. then returned baseline levels, CTX-I continued increase. RVE RE, increased more control (p ≤ 0.029). Increases RE did not differ significantly control. may have attenuated dickkopf-1, but this was statistically significant. there evidence for any on changes. Long-term recovery also 6–24 months rest, proximal femur mineral content still greater 0.01). results, while showing results formation, could provide impeded the rise levels.