A Quantitative Survey of Bacterial Persistence in the Presence of Antibiotics: Towards Antipersister Antimicrobial Discovery.

作者: Jesus Enrique Salcedo-Sora , Douglas B. Kell

DOI: 10.3390/ANTIBIOTICS9080508

关键词:

摘要: Background: Bacterial persistence to antibiotics relates the phenotypic ability survive lethal concentrations of otherwise bactericidal antibiotics. The quantitative nature time–kill assay, which is sector’s standard for study antibiotic bacterial persistence, an invaluable asset global, unbiased, and cross-species analyses. Methods: We compiled results from antibiotic-sensitive bacteria during planktonic growth. data were extracted a sample 187 publications over last 50 years. used in this compilation also compared terms structural similarity fluorescent molecules known accumulate Escherichia coli. Results: reviewed detail 54 36 species. Persistence varies widely as function type (membrane-active admit fewest), growth phase medium (persistence less common exponential rich media), Gram staining target organism more positives). Some bear strong fluorophores be taken up by E. coli, potentially allowing competitive assays. also, paradoxically, seem allow persisters at higher concentrations. Conclusions: consolidated actionable knowledge base support rational development antipersister antimicrobials. seen step on pathway antimicrobial resistance, we found no organisms that failed exhibit it. Novel need have activity. Discovery strategies should include persister-specific approaches could find preferably membrane structure permeability slow-growing cells.

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