Design of an environmentally sensitive fluorescent 8-aza-7-deaza-2′-deoxyadenosine derivative with dual fluorescence for the specific detection of thymine
作者： Azusa Suzuki , Nobukatsu Nemoto , Isao Saito , Yoshio Saito
DOI: 10.1039/C3OB41757C
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摘要: A novel environmentally sensitive fluorescent (ESF) purine nucleoside, cnaA, was synthesized and its photophysical properties were investigated. The base-modified nucleoside cnaA exhibited remarkable solvatochromicity dual fluorescence. By using we have developed highly thymine (T) selective DNA probes that can sense the corresponding T in a target DNA/RNA sequence, as measured by distinct change emission wavelength.
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