The relationship of pineal calcification and melatonin secretion to the pathophysiology of tardive dyskinesia and Tourette's syndrome.

摘要: Despite current intensive research, the pathophysiology of tardive dyskinesia (TD), a serious neurological side effect neuroleptic treatment, is poorly understood. Prompted by observation an increased incidence and severity abnormal perioral movements in neuroleptic-treated pinealectomized, as compared to intact rats, we suggested that pineal gland exerts protective which mitigates against development TD and, inference, reduced melatonin secretion may be related TD. To investigate this proposition further, studied association with calcification (PC) on CT scan chronic schizophrenic patients. Our findings revealed significant between PC suggest, furthermore, neuroradiological marker Since reflect diminished secretory activity gland, these support hypothesis linked disturbances secretion. The clinical therapeutic implications novel are discussed. In following communication, introduce 5-HT Subsequently, present series studies relate PC. We conclude presenting also relevant Tourette's syndrome.