Genetic mapping of a naturally occurring hereditary renal cancer syndrome in dogs
作者： T. J. Jonasdottir , C. S. Mellersh , L. Moe , R. Heggebo , H. Gamlem
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摘要: Canine hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis (RCND) is a rare, naturally occurring inherited cancer syndrome observed in dogs. Genetic linkage analysis of an RCND-informative pedigree has identified group flanking RCND (CHP14-C05.377-C05.414-FH2383-C05.771-[RCND-CPH18]-C02608-GLUT4-TP53-ZuBeCa6-AHT141-FH2140-FH2594) thus localizing the disease to small region canine chromosome 5. The closest marker, C02608, linked with recombination fraction (θ) 0.016, supported by logarithm odds score 16.7. C02608 adjacent markers map genome corresponding portions human chromosomes 1p 17p. A combination direct sequencing eliminate several likely candidate genes, including tuberous sclerosis 1 2 genes (TSC1 TSC2) tumor suppressor gene TP53. These data suggest that may be caused previously unidentified highlight potential for genetics study predisposition.
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