Subpopulations of apolipoprotein A-I in human high-density lipoproteins. Their metabolic properties and response to drug therapy.

摘要: Abstract In this study immunological procedures were used to detect and quantify high-density lipoprotein (HDL) particles of differing apolipoprotein A composition. the plasma eight healthy female subjects, 45% total A-I existed in (called ‘(AI)HDL’) devoid A-II. The remainder circulated association with A-II at a molar ratio approximately 1:1. Nicotinic acid selectively raised A-I/A-II by increasing proportion (AI)HDL particles. Probucol produced opposite effect, lowering concentration these kinetic properties HDL particle same despite fact that equilibration between two species was incomplete. Therefore, there appear be least A-containing populations which are immunochemically metabolically distinct.