Use of tissue culture to examine the actions of guanethidine and 6-hydroxydopamine
作者： Caryl E. Hill , Gerda E. Mark , Olavi Eränkö , Liisa Eränkö , Geoffrey Burnstock
DOI: 10.1016/0014-2999(73)90052-6
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摘要: Abstract Cultures of newborn rat and embryo chick sympathetic ganglia have been used to compare the effects 6-hydroxydopamine guanethidine in vitro. In sufficient concentrations both drugs had a direct cytotoxic effect on neurons, eventually resulting cell death. The major difference between actions two was that caused nerve fibre fragmentation while retraction. uptake these by bodies their processes is discussed relation toxic effects.
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G. Burnstock, B. J. Gannon, B. K. Evans, J. W. Heath, V. B. James, Degeneration of adrenergic neurons following guanethidine treatment: an ultrastructural study. Virchows Archiv B Cell Pathology. ,vol. 11, pp. 182- 197 ,(1972) , 10.1007/BF02889397
Joseph Pick, The autonomic nervous system : morphological, comparative, clinical, and surgical aspects Lippincott. ,(1970)
Olavi Er�nk�, Liisa Er�nk�, Histochemical evidence of chemical sympathectomy by guanethidine in newborn rats. Histochemical Journal. ,vol. 3, pp. 451- 456 ,(1971) , 10.1007/BF01014783
Olavi Er�nk�, Liisa Er�nk�, Loss of histochemically demonstrable catecholamines and acetylcholinesterase from sympathetic nerve fibres of the pineal body of the rat after chemical sympathectomy with 6-hydroxydopamine Histochemical Journal. ,vol. 3, pp. 357- 363 ,(1971) , 10.1007/BF01005017
J. P. Tranzer, G. Häusler, H. Thoenen, Chemical Sympathectomy with 6-Hydroxydopamine Springer, Berlin, Heidelberg. pp. 130- 143 ,(1970) , 10.1007/978-3-642-46241-2_13
G. Burnstock, B. J. Gannon, Barbara Evans, J. W. Heath, Vicki James, A new method of destroying adrenergic nerves in adult animals using guanethidine. British Journal of Pharmacology. ,vol. 43, pp. 295- 301 ,(1971) , 10.1111/J.1476-5381.1971.TB08060.X
Liisa Eränkö, Olavi Eränkö, Effect of guanethidine on nerve cells and small intensely fluorescent cells in sympathetic ganglia of newborn and adult rats. Pharmacology & Toxicology. ,vol. 30, pp. 403- 416 ,(2009) , 10.1111/J.1600-0773.1972.TB00672.X
Lewis S. Schanker, Anne S. Morrison, PHYSIOLOGICAL DISPOSITION OF GUANETHIDINE IN THE RAT AND ITS UPTAKE BY HEART SLICES. Neuropharmacology. ,vol. 4, pp. 27- 39 ,(1965) , 10.1016/0028-3908(65)90044-4
P.U. Angeletti, Chemical sympathectomy in newborn animals Neuropharmacology. ,vol. 10, pp. 55- 59 ,(1971) , 10.1016/0028-3908(71)90008-6
Liisa Eränkö, Olavi Eränkö, Effect of 6-hydroxydopamine on the ganglion cells and the small intensely fluorescent cells in the superior cervical ganglion of the rat. Acta Physiologica Scandinavica. ,vol. 84, pp. 115- 124 ,(1972) , 10.1111/J.1748-1716.1972.TB05161.X