Genetic Relatedness of WNIN and WNIN/Ob with Major Rat Strains in Biomedical Research
作者： Kiran Kumar Battula , Giridharan Nappanveettil , Satoshi Nakanishi , Takashi Kuramoto , Jeffry M. Friedman
DOI: 10.1007/S10528-015-9679-8
关键词:
摘要: WNIN (Wistar/NIN) is an inbred rat strain maintained at National Institute of Nutrition (NIN) for more than 90 years, and WNIN/Ob obese mutant originated from it. To determine their genetic relatedness with major strains in biomedical research, they were genotyped various marker loci. The recently identified markers albino hooded mutations which clustered all the known rats into a single lineage also included rats. Genotyping using microsatellite DNA phylogenetic analysis 49 different suggested that shares common ancestor many Wistar strains. Fst estimates Fischer’s exact test suggest differed significantly other tested. though shows hyper-leptinemia, like Zucker fatty rat, did not share mutation. above analyses as highly differentiated novel evolved
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