摘要: Food intake is rapidly and reliably reduced when animals are offered diets that result in an essential amino acid deficiency, such as those used the imbalanced diet (IMB) paradigm. There seem to be at least three phases responses of rats IMB: 1) In order respond a dietary challenge, must first recognize challenge. The available data suggest before behavioral effects occur, decline concentration sensed specific brain area, prepyriform cortex. This recognition phase associated with localized decreases concentrations limiting acid, norepinephrine cyclic AMP altered protein synthesis. 2) Subsequent conditioned taste aversion develops, mediated part by serotonin level vagus. 3) Finally, absence choice, adapt IMB (but not devoid one or more acids) approximately 1 wk. Damage certain extrahypothalamic areas liver denervation accelerates adaptation IMB, suggesting both central peripheral control phase. resulting provide adaptive advantage animal selection appropriate balance acids.