Acquired FV inhibitors: a needless iatrogenic complication of bovine thrombin exposure.

摘要: BACKGROUND: FV inhibitors are a largely preventable iatrogenic coagulopathy in which the frequency is increasing clinical practice. STUDY DESIGN AND METHODS: Three cases associated with our institution reported. A systematic review of MEDLINE database was performed, and reference lists were reviewed to identify relevant publications. RESULTS: One hundred twenty-six have been reported world's literature. Eighty-seven last decade, two thirds due exposure bovine thrombin. Bovine thrombin-associated antibodies develop 40 66 percent cardiac surgery patients 20 neurosurgery patients. Thirty-three developed bleeding complications. Inhibitors persisted on average 2.3 months. Standard coagulation assays do not reliably predict manifestations. Multimodality therapy, including immunosuppression, useful for treatment symptomatic patients. CONCLUSIONS: common complication thrombin that can devastating consequences. Transfusion medicine specialists hematologists play critical role reducing incidence by educating medical community about safer alternative fibrin sealants.