Comparison of cardioprotective effects of salvianolic acid B and benazepril on large myocardial infarction in rats.
作者： Xian-Zhe Yang , Meng-Qiong Shi , Li-Mao Wu , Lian-Da Li , Xiao-Wei Zeng
DOI:
关键词:
摘要: In the present study, we compared cardioprotective effects of salvianolic acid B (Sal B) and angiotension-converting enzyme inhibitor, benazepril, in rats with large myocardial infarction (MI). The MI was produced by coronary artery ligation for 4 weeks rats. were divided into following groups: sham operation; MI; + Sal (100 mg/kg a gavage, once day weeks) benazepril (1 weeks). Echocardiogram, hemodynamic hemorheological changes, angiogenesis, infarct size cardiac remodeling, as well messenger ribonucleic (mRNA) vascular endothelium growth factor (VEGF) measured. similar observed treated benazepril: (1) marked improvement echocardiographic, parameters, (2) significant reduction size, (3) significantly attenuated heart hypertrophy, left ventricular (LV) dilatation fibrosis. unique were: angiogenesis augmented VEGF expression border remote noninfarcted LV area. These results suggest that exerted beneficial effects. However, enforced some different modality than which might improve microcirculation augmenting promoting besides to benazepril.
参考文章(36)
M. C. Fishbein, D. Maclean, P. R. Maroko, Experimental myocardial infarction in the rat: qualitative and quantitative changes during pathologic evolution. American Journal of Pathology. ,vol. 90, pp. 57- 70 ,(1978)
Hou Jw, Xin Wj, Jiang W, Zhao Y, Zhao Bl, Scavenging effects of salvia miltiorrhiza on free radicals and its protection for myocardial mitochondrial membranes from ischemia-reperfusion injury. Iubmb Life. ,vol. 38, pp. 1171- 1182 ,(1996)
S. V. Nicosia, R. F. Nicosia, M. Smith, Vascular endothelial growth factor, platelet-derived growth factor, and insulin-like growth factor-1 promote rat aortic angiogenesis in vitro. American Journal of Pathology. ,vol. 145, pp. 1023- 1029 ,(1994)
Takeshi Soeki, Ichiro Kishimoto, Hiroyuki Okumura, Takeshi Tokudome, Takeshi Horio, Kenji Mori, Kenji Kangawa, C-type natriuretic peptide, a novel antifibrotic and antihypertrophic agent, prevents cardiac remodeling after myocardial infarction. Journal of the American College of Cardiology. ,vol. 45, pp. 608- 616 ,(2005) , 10.1016/J.JACC.2004.10.067
T. Na, D. Z. Dai, X. Y. Tang, Y. Dai, Upregulation of leptin pathway correlates with abnormal expression of SERCA2a, phospholamban and the endothelin pathway in heart failure and reversal by CPU86017. Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 375, pp. 39- 49 ,(2007) , 10.1007/S00210-007-0134-1
Justin D. Pearlman, Mark G. Hibberd, Michael L. Chuang, Kazumasa Harada, John J. Lopez, Stephen R. Gladstone, Menahem Friedman, Frank W. Sellke, Michael Simons, Magnetic resonance mapping demonstrates benefits of VEGF–induced myocardial angiogenesis Nature Medicine. ,vol. 1, pp. 1085- 1089 ,(1995) , 10.1038/NM1095-1085
Sanyin Zhang, Shilin Chen, Yingjun Shen, Dajian Yang, Xijing Liu, Albert Chan Sun-chi, Hongxi Xu, Puerarin induces angiogenesis in myocardium of rat with myocardial infarction. Biological & Pharmaceutical Bulletin. ,vol. 29, pp. 945- 950 ,(2006) , 10.1248/BPB.29.945
Limin Zhou, Moses Chow, Zhong Zuo, Improved quality control method for Danshen products--consideration of both hydrophilic and lipophilic active components. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 41, pp. 744- 750 ,(2006) , 10.1016/J.JPBA.2005.12.032
Saul Benedict Freedman, Jeffrey M. Isner, Therapeutic angiogenesis for ischemic cardiovascular disease. Journal of Molecular and Cellular Cardiology. ,vol. 33, pp. 379- 393 ,(2001) , 10.1006/JMCC.2000.1329
Yong-Qing Wang, Yan-Ping Shi, De-Zai Dai, Therapeutic effects of CPU 86017 on acute and chronic congestive cardiac failure mediated by reducing ET-1?NOS and oxidative stress in rats Drug Development Research. ,vol. 63, pp. 22- 32 ,(2004) , 10.1002/DDR.10383