Lung Magnetic Resonance Imaging with Diffusion Weighted Imaging Provides Regional Structural as well as Functional Information Without Radiation Exposure in Primary Antibody Deficiencies

摘要: Primary antibody deficiency patients suffer from infectious and non-infectious pulmonary complications leading over time to chronic lung disease. The complexity of this involvement poses significant challenge in differential diagnosis with long life disease increased radio sensitivity. We planned verify the utility chest Magnetic Resolution Imaging Diffusion-Weighted as a radiation free technique. Prospective evaluation 18 Common Variable Immunodeficiency X-linked Agammaglobulinemia. On same day, underwent Resonance Diffusion Weighted sequences, High Computerized Tomography Pulmonary Function Tests, including diffusing capacity factor for carbon monoxide. Images were scored using modified version Bhalla scoring system. was non-inferior identify bronchial parenchymal abnormalities. HRCT had higher peripheral airways abnormalities, defined an generation up fifth distal (scores 2–3). Bronchial scores negatively related function tests. One third consolidations nodules restrictions associated systemic granulomatous lymphadenopathy. Lung detected improvement recently diagnosed soon after starting Ig replacement. reliable technique detect alterations Antibody Deficiencies.